Waikiki Brothers is a band going nowhere. After another depressing gig, the saxophonist quits, leaving the three remaining members to continue on the road. The band ends up at the lead singer's hometown, which was a popular hot spring resort in the '80s, but the return home is filled with reservations of previous and past disappointments, a lost love, unemployment and tragedy.
Tony Marvin is a laid back but incredibly successful promoter and fair-haired boy for J. P. Todhunter's pineapple company located in beautiful Hawaii. He gets the company to sponsor a contest in which the winner gets a Hawaiian vacation and is obligated to write articles on the islands which, when published, will constitute a publicity coup for the company. Unfortunately, Georgia Smith, the winner, feels lonely and isolated in the Islands and wants to return to the States. With help from buddy Shad Buggle Tony tries to romantically divert Georgia without letting her know his true motivation.
Dr. Dawn "Holli" Holliday (played by Cheryl Ladd), a forensics expert formerly of the Los Angeles Coroner's Office is appointed as the State of Hawaii's Medical Examiner. She finds herself at odds with Lt. Mack Wolfe (played by Richard Burgi), Honolulu PD's No.1 homicide detective. They have a love-hate relationship yet they must cooperate in order to solve various crimes.
Ma and Pa, along with daughter Rosie, go off to Hawaii in answer to cousin Rodney's call for help running his pineapple farm while he recovers from an illness. Pa soon causes a major explosion and gets himself kidnapped.
Kang Dong-Goo dreams of becoming a movie director, but he is cynical due to bad luck. Cheon Joon-Ki wanted to follow in his father's footsteps and become an actor, but he is now just a minor actor. Bong-Doo-Sik came to Seoul to become a scenario writer, but things have not been easy for him. These 3 men run the guest house Waikiki in Itaewon, South Korea. Their guest house is facing bankruptcy and then a mysterious baby and single mother appear at Waikiki.